Factoring,
224−1=(212−1)(212+1)=(26−1)(26+1)⋅(24+1)(28−24+1), which equals
63⋅65⋅17⋅241 =32⋅5⋅7⋅13⋅17⋅241.
Since
241 is a three-digit prime, the two-digit factors come from
32⋅5⋅7⋅13⋅17. They are
13,15,17,21,35,39,45,51,63,65,85,91, for a total of
12.
Thus, the correct answer is
D.